Blar i NIVA Open Access Archive på forfatter "Song, You"
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17α-Ethinylestradiol (EE2) effect on global gene expression in primary rainbow trout (Oncorhynchus mykiss) hepatocytes
Hultman, Maria Therese; Song, You; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2015)The potential impact of endocrine disrupting chemicals (EDCs) in the aquatic environment has driven the development of screening assays to evaluate the estrogenic properties of chemicals and their effects on aquatic organisms ... -
Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network
Tollefsen, Knut Erik; Alonzo, Frederic; Beresford, Nicholas A.; Brede, Dag Anders; Dufourcq-Sekatcheff, Elizabeth; Gilbin, Rodolphe; Horemans, Nele; Hurem, Selma; Laloi, Patrick; Maremonti, Erica; Oughton, Deborah Helen; Simon, Olivier; Song, You; Wood, Michael; Xie, Li; Frelon, Sandrine (Peer reviewed; Journal article, 2022)Reproductive effects of ionizing radiation in organisms have been observed under laboratory and field conditions. Such assessments often rely on associations between exposure and effects, and thus lacking a detailed ... -
Age and Synchronization of Daphnia magna Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests
Nordblad Schmidt, Simon; Rundberget, Thomas; Song, You; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2023)The standard Daphnia sp. acute toxicity test for assessing the adverse effects of chemicals on aquatic invertebrates stipulates the use of neonates that are ≤24 h old (hours post release [hpr]) at the start of the exposure. ... -
Aggregate exposure pathways for microplastics (mpAEP): An evidence-based framework to identify research and regulatory needs
Peng, Guyu; Lin, Yan; van Bavel, Bert; Li, Daoji; Ni, Jinren; Song, You (Peer reviewed; Journal article, 2022)Microplastics as emerging contaminants have been detected from peaks to poles. High concerns on the risks of microplastic pollution to humans and ecosystems have therefore been raised in the past decade. While a large ... -
AOP Report: Inhibition of Chitin Synthase 1 Leading to Increased Mortality in Arthropods
Schmid, Simon; Song, You; Tollefsen, Knut Erik (Peer reviewed; Journal article, 2021) -
AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation
Song, You; Villenueve, Daniel L. (Peer reviewed; Journal article, 2021)This report describes a novel adverse outcome pathway (AOP) on uncoupling of oxidative phosphorylation (OXPHOS) leading to growth inhibition via decreased adenosine triphosphate (ATP) pool and cell proliferation (AOPWiki, ... -
Ciona spp. and ascidians as bioindicator organisms for evaluating effects of endocrine disrupting chemicals: A discussion paper
Beyer, Jonny; Song, You; Lillicrap, Adam David; Rodríguez-Satizábal, Simón; Chatzigeorgiou, Marios (Peer reviewed; Journal article, 2023)In context of testing, screening and monitoring of endocrine-disrupting (ED) type of environmental pollutants, tunicates could possibly represent a particularly interesting group of bioindicator organisms. These primitive ... -
Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network
Cao, Yang; Moe, S. Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You (Peer reviewed; Journal article, 2023)Quantitative adverse outcome pathway network (qAOPN) is gaining momentum due to the predictive nature, alignment with quantitative risk assessment and great potential as a computational new approach methodology (NAM) to ... -
Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: A Conceptual Approach
Song, You; Asselman, Jana; De Schamphelaere, Karel A. C.; Salbu, Brit; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2018)The use of classical mixture toxicity models to predict the combined effects of environmental stressors based on toxicogenomics (OMICS) data is still in its infancy. Although several studies have made attempts to implement ... -
Dose-dependent hepatic transcriptional responses in Atlantic salmon (Salmo salar) exposed to sublethal doses of gamma radiation
Song, You; Salbu, Brit; Teien, Hans-Christian; Heier, Lene Sørlie; Rosseland, Bjørn Olav; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Due to the production of free radicals, gamma radiation may pose a hazard to living organisms. The high-dose radiation effects have been extensively studied, whereas the ecotoxicity data on low-dose gamma radiation is still ... -
Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development
Song, You; Villeneuve, Daniel L.; Toyota, Kenji; Iguchi, Taisen; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2017)Molting is critical for growth, development, reproduction and survival in arthropods. Complex neuroendocrine pathways are involved in the regulation of molting and may potentially become targets of environmental endocrine ... -
Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia
Miyakawa, Hitoshi; Sato, Tomomi; Song, You; Tollefsen, Knut Erik; Iguchi, Taisen (Journal article; Peer reviewed, 2018)The two essential insect hormones, ecdysteroids and juvenile hormones, are possessed not only by insects, but also widely by arthropods, and regulate various developmental and physiological processes. In contrast to the ... -
The ecotoxicology of marine tributyltin (TBT) hotspots: A review
Beyer, Jonny; Song, You; Tollefsen, Knut-Erik; Berge, John Arthur; Tveiten, Lise Ann; Helland, Aud; Øxnevad, Sigurd; Schøyen, Merete (Peer reviewed; Journal article, 2022)Tributyltin (TBT) was widely used as a highly efficient biocide in antifouling paints for ship and boat hulls. Eventually, TBT containing paints became globally banned when TBT was found to cause widespread contamination ... -
Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization
Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)Macrophytes inhabit waterways around the world and are used in hydroponics or aquaponics for different purposes such as feed and wastewater treatment and are thus exposed to elevated levels of UVB from natural and artificial ... -
Environmental risk assessment of combined effects in aquatic ecotoxicology: A discussion paper
Beyer, Jonny; Petersen, Karina; Song, You; Ruus, Anders; Grung, Merete; Bakke, Torgeir Heggelund; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Environmental regulatory edicts within the EU, such as the regulatory framework for chemicals REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), the Water Framework Directive (WFD), and the Marine ... -
Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation
Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; YeonKyeong, Lee; Xie, Li; Aleström, Peter; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)Ionizing radiation is known to induce oxidative stress and DNA damage as well as epigenetic effects in aquatic organisms. Epigenetic changes can be part of the adaptive responses to protect organisms from radiation-induced ... -
Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine
Lindeman, Leif Christopher; Thaulow, Jens; Song, You; Kamstra, Jorke H; Xie, Li; Asselman, Jana; Alestrøm, Peter; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2019)The water flea Daphnia magna is a keystone species in freshwater ecosystems and has been widely used as a model organism in environmental ecotoxicology. This aquatic crustacean is sensitive to environmental stressors and ... -
Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna
Gomes, Tania; Song, You; Brede, Dag Anders; Xie, Li; Gutzkow, Kristine Bjerve; Salbu, Brit; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2018)Among aquatic organisms, invertebrate species such as the freshwater crustacean Daphnia magna are believed to be sensitive to gamma radiation, although information on responses at the individual, biochemical and molecular ... -
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium
Song, You; Salbu, Brit; Teien, Hans-Christian; Heier, Lene Sørlie; Rosseland, Bjørn Olav; Høgåsen, Tore; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of ... -
Hepatic transcriptional responses in Atlantic salmon (Salmo salar) exposed to gamma radiation and depleted uranium singly and in combination
Song, You; Salbu, Brit; Teien, Hans-Christian; Evensen, Øystein; Lind, Ole Christian; Rosseland, Bjørn Olav; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2016)Radionuclides are a special group of substances posing both radiological and chemical hazards to organisms. As a preliminary approach to understand the combined effects of radionuclides, exposure studies were designed using ...